Clearing the cache from server level
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Login or sudo as root user and follow below steps to release the memory from vm level

sync; echo 3 > /proc/sys/vm/drop_caches

Steps to de-registration and registration of SSO
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Set the apps env

Go to $FND_TOP/bin

Then execute
--->$txkrun.pl -script=SetSSOReg -deregisteroid=Yes

Give values for the prompts as below:
Enter Oracle E-Business apps database user password ?
Checking preferences in the database.
Enter the host name where Oracle iAS Infrastructure database is installed ?
Enter the application name used for registration of this application instance in OID ( 24 chars or less ) ?
Enter the descriptive service name used for registration of this application instance in OID ( 80 chars or less ?
Enter the descriptive service name used for registration of this application instance in OID ( 80 chars or less ) ?
Enter the LDAP Port on Oracle Internet Directory server ?
Enter the Oracle Internet Directory Administrator (orcladmin) Bind password ?
after deregistering do the below
copy and paste the below

---> txkrun.pl -script=SetSSOReg \
-registeroid=Yes \
-appspass=\
-infradbhost= \
-orcladminpass= \
-instpass= \
-ldapport= \
-appname="" \
-svcname="e" \
-provtmp=$FND_TOP/admin/template/ProvOIDToApps.tmp

The below command can help to remove the locks from filer level

ssh us04fl11 "priv set -q advanced; sm_mon -l us01u418"

Steps to restart the Em12c agent.
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./emctl stop agent
./emctl clearstate agent
./emctl start agent
./emctl upload agent